2014 Fiscal Year Final Research Report
Regulation of abdominal aortic aneurysms by calpain/calpastatin systems
| Project/Area Number |
24790784
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 腹部大動脈瘤 / 血管新生 / 血管内皮細胞 / 癌 / 網膜症 / カルパイン |
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| Outline of Final Research Achievements |
Calpain, an intracellular multi-functional protease, reportedly participates in the various disorders including cardiovascular diseases. We herein revealed that the calpain systems are over-activated in vascular endothelial cells in abdominal aortic aneurysm in mice. The mice lacking calpain activity specifically in vascular endothelial cells exhibited normalization of adventitial immatured neovessels, thereby suppressing progression of aneurysms. Similar normalization of neovessels was detectable in cancer transplantation models and retinopathy models in mice, and was due to the over-activation of JAK/STAT inflammatory signals. These data suggests that calpain inhibition is promising approach for targeting pathological angiogenesis and related diseases.
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| Free Research Field |
血管生物学
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