2014 Fiscal Year Final Research Report
Airway dimensions and emphysema measured by Three-dimensional Computed Tomography in Bronchial asthma and Chronic obstructive pulmonary disease
| Project/Area Number |
24790796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 3次元気道解析 / 慢性閉塞性肺疾患 / 気管支拡張薬 / 気腫 / 気道の虚脱 |
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| Outline of Final Research Achievements |
Our study has shown that the determinant of bronchodilator response in salmeterol fluticason propionate combination might be the 3rd to the 6th generation of bronchi in COPD, which was different from the determinant that we have previously reported in tiotropium. The collapsibility of bronchi is one of the characteristics in COPD.From full inspiration to expiration, the airway luminal area shrinks more at the distal airways compared with the proximal airways and in the lower lobe compared with the other lobes. Generally, the airways shrink more as COPD severity progresses.
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| Free Research Field |
呼吸器内科学
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