2013 Fiscal Year Final Research Report
Analysis of leukemogenesis through the NPM fusion gene
| Project/Area Number |
24790971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWAHARA Masahiro 京都大学, 医学(系)研究科(研究院), 助教 (80617449)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 白血病 / 造血幹細胞 / NPM1 / MLF1 |
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| Research Abstract |
We analyzed a mechanism for leukemogenesis through the NPM-MLF1 fusion gene and overexpression of wild-type MLF1. We found that clonogenic capacity is transiently enhanced and Kit-positive immature hematopoietic cells are increased by transduction of NPM-MLF1 and MLF1 into murine hematopoietic stem and progenitor cells (HSPCs), and MLF1 expression level is high in hematopoietic stem cells but decreases as differentiation, indicating that NPM-MLF1 and overexpression of MLF1 might contribute to leukemogenesis through dysregulation of normal differentiation of HSPCs.
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[Journal Article] H2.0-like homeobox (HLX) regulates early hematopoiesis and promotes acute myeloid leukemia2012
Author(s)
Kawahara M, Pandolfi A, Bartholdy B, Barreyro L, Will B, Roth M, Okoye UC, Todorova T, Figueroa ME, Melnick A, Mitsiades CS, Steidl U
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Journal Title
Cancer Cell
Volume: 22
Pages: 194-208
DOI
Peer Reviewed
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