2013 Fiscal Year Final Research Report
Development and application of multiple quantum coherence MRI for the analysis of lipid composition in vivo
| Project/Area Number |
24791303
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
SUGIHARA Fuminori 大阪大学, 免疫学フロンティア研究センター, 特任助教 (50381645)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | MRI / 多重共鳴 / 脂質 / 肥満 |
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| Research Abstract |
Adipose tissue is known as energy storage and also heat generator at the brown adipose tissue. Excess amount of energy intake such as sugar and fat lead obesity, in which the adipose tissue hold extra lipid and also secret inflammation cytokine. Imaging devices are used for diagnosis of obesity. MRI is one of the imaging tool and able to observe not only the area of adipose tissue but also used for analysis of lipid composition in detail.
In this study, multiple quantum coherence MRI method was used for imaging lipid composition in vivo using model animal under various conditions. As the results of time course observation with induced obesity, it was revealed that the lipid composition of saturated-unsaturated lipid was change at the adipose tissue.
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