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2013 Fiscal Year Annual Research Report

3テスラMRスペクトロスコピーによる婦人科腫瘍の非侵襲病理組織診断の検討

Research Project

Project/Area Number 24791310
Research InstitutionThe University of Tokushima

Principal Investigator

竹内 麻由美  徳島大学, 大学病院, 講師 (90423417)

KeywordsMRスペクトロスコピー / 女性骨盤部 / 婦人科腫瘍 / 骨盤部膿瘍
Research Abstract

前年度に引き続き、3テスラMRI装置を用いて婦人科腫瘍を有する臨床症例についてMRスペクトロスコピーの測定を行った。得られた各代謝物ピークの定性解析および定量解析データをもとに病理組織との対比検討を行い、報告したpreliminary studyの内容について検証した。子宮体部腫瘍における良性の平滑筋腫と悪性の子宮肉腫との鑑別に壊死を反映するlipidのピークが有用であること(European Radiology, 2013)、および卵巣莢膜細胞腫の診断における細胞内脂質のピークの検出の有用性 (JMRI, 2012)について、いずれも報告した所見に合致するデータが得られた。骨盤部膿瘍については、起炎菌と代謝物ピークとの対比検討により嫌気性菌感染の症例で検出される解糖系の亢進や発酵に伴うacetateおよびsuccinateのピークによる起炎菌同定への有用性について論文報告を行った(JMRI, 2013)。また、質的診断におけるスペクトル・パターンの有用性についての検討を含む女性骨盤部の嚢胞性病変のMRIによる鑑別について、およびMRSによる微量な脂質成分の検出による診断能の向上についての知見を含む卵巣奇形腫の画像診断について、北米放射線学会(2013.12) にて展示発表を行い、いずれの演題もCertificate of Merit賞を受賞した。演題名:Diagnostic Strategy for Cystic Masses in the Female Pelvis: A Comprehensive Review and Diagnostic Impact of Advanced MR Techniques (女性骨盤部嚢胞性病変の診断ストラテジー)、Many Faces of Ovarian Teratomas: Usual, Unusual Imaging Manifestations, Pitfalls, and Problem-solving MR Techniques (卵巣奇形腫の画像診断とピットフォール)。

  • Research Products

    (12 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] In vivo proton MR spectroscopy in uterine abscesses2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M
    • Journal Title

      J Magn Reson Imaging

      Volume: 38(4) Pages: 955-957

    • DOI

      10.1002/jmri.24241

    • Peer Reviewed
  • [Journal Article] Preliminary observations and clinical value of lipid peak in high-grade uterine sarcomas using in vivo proton MR spectroscopy2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M
    • Journal Title

      Eur Radiol

      Volume: 23(9) Pages: 2358-2363

    • DOI

      10.1007/s00330-013-2856-4

    • Peer Reviewed
  • [Presentation] Carcinosarcoma of the Uterus: MR Findings including Diffusion-weighted imaging and in-vivo proton MR Spectroscopy2014

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      ISMRM 2014
    • Place of Presentation
      Milano Congressi (Milano, Italy)
    • Year and Date
      20140510-20140516
  • [Presentation] Differential diagnosis of cystic masses in the female pelvis based on the conventional MRI findings and the added value of advanced MRI techniques2014

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      ECR 2014
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Year and Date
      20140306-20140310
  • [Presentation] Diagnostic and Therapeutic Strategy for Uterine Cervical Lesions2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Diagnostic and Therapeutic Strategy for Secondary Malignant Involvement of Gynecologic Organs2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Problem-solving MR Spectroscopy in Gynecologic Lesions: Challenging Cases in which MRS is Helpful in Refining the Diagnosis2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Diagnostic Strategy for Benign Tumor-like Lesions Mimicking Malignancy in the Female Pelvis2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Diagnostic Strategy for Cystic Masses in the Female Pelvis: A Comprehensive Review and Diagnostic Impact of Advanced MR Techniques2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Clinical Impact of Lipid Detection in Gynecologic Pathologies by Advanced MR Techniques2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Many Faces of Ovarian Teratomas: Usual, Unusual Imaging Manifestations, Pitfalls, and Problem-solving MR Techniques2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      RSNA 2013
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      20131201-20131206
  • [Presentation] Diffusion-weighted MR imaging and MR spectroscopy in the assessment of tumor grade and depth of myometrial invasion in malignant endometrial tumors2013

    • Author(s)
      Takeuchi M, Matsuzaki K, Harada M.
    • Organizer
      ISMRM 2013
    • Place of Presentation
      Salt Palace Convention Center (Salt Lake City, USA)
    • Year and Date
      20130420-20130426

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Published: 2015-05-28  

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