Development of a safe and efficient stimulation electrode and stimulation method of intraoperative MEP monitoring

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791492
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Shinshu University
• Principal Investigator: KODAMA Kunihiko 信州大学, 医学部附属病院, 特任研究員 (50432183)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 術中運動誘発電位 / 電気生理学的モニタリング / 脳神経外科手術

Outline of Final Research Achievements

This study was intended to establish a safe and efficient stimulation electrodes and stimulation method of intraoperative motor evoked potential (MEP) monitoring in neurosurgery. In this study, the rat brain injury model was established for in vivo assessment by brain cortical MEP stimulation. The four parameters of MEP stimulation, intensity of the stimulus, stimulation time, number and frequency were changed and examined.　It was clarified that the damage of the brain was proportional to the total electric power amount applied on the brain. If the total amount of electric power is the same, the larger number of stimulus and stimulus intensity causes more damage on the brain compared to the stimulation time. It was also discovered that the MEP threshold tends larger in biphasic stimulation than monophasic stimulation. These findings will support a safer and more efficient intraoperative MEP monitoring in neurosurgery.

Free Research Field

脳神経外科学