2014 Fiscal Year Final Research Report
Investigation with fMRI into the expression mechanism for acute pain in the central nervous system
| Project/Area Number |
24791585
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Mitsuaki 富山大学, 大学院医学薬学研究部(医学), 教授 (70158145)
NARITA Minoru 星薬科大学, 大学院薬学研究科薬学専攻治療薬学領域薬理学, 教授 (40318613)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | fMRI / 急性痛 / 炎症性痛 / 神経障害性痛 / 疼痛発現機構 / 痛み関連脳領域 |
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| Outline of Final Research Achievements |
It’s important to prevent acute pain from transiting into chronic pain. In this study we investigated, with fMRI, the expression mechanism for acute pain in the brain of mice.
Firstly, we investigated the pain of acute pancreatitis, which is difficult to cure clinically. The investigation showed that the activating pathways for acute pain in the brain were different from the ones for chronic pain. Secondly, we investigated cases of inflammatory pain and neuropathic pain. In both cases, the investigation showed that the pain matrix of the brain related to chronic pain was activated. Moreover, the brain hyperactivities were suppressed by an analgesic and an analgesic adjuvant. In brief, the investigation indicated that, even if we were under general anesthesia, there is an increase in the transmission of pain in the brain by pain stimuli. Therefore, it is necessary to use enough quantity of analgesics for patients from the middle of operations.
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| Free Research Field |
麻酔科学、疼痛管理学
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