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2013 Fiscal Year Final Research Report

Study of a new therapy targeting proteins of high-risk HPV

Research Project

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Project/Area Number 24791719
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

OHNO Akiko  慶應義塾大学, 医学部, 共同研究員 (70383883)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsHPV
Research Abstract

Adenovirus vector expressing IgG signal peptide(ss)-cell penetrating peptide(Atp)-E7 pRb-binding peptide(RbB)-E7 c-myc-binding peptide(MycB)-pentameric COMP domain peptide(COMP)-6xHis was constructed. Several deletion variants as well as vector containing partial HPV E6 peptide were also generated. Cell lines such as HeLa, CaSki, C33a, and A431 were infected with these adenoviruses to examine the cytotoxicity. Growth inhibition was observed only in HPV18 positive HeLa.

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Published: 2015-06-25   Modified: 2015-08-12  

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