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2014 Fiscal Year Final Research Report

Examination of inner ears of mice using 7T MRI and molecular biologic analysis

Research Project

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Project/Area Number 24791813
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

NAKAMURA Manabu  聖マリアンナ医科大学, 医学部, 助教 (60386969)

Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsMRI / 内リンパ水腫
Outline of Final Research Achievements

Endolymphatic hydrops may be involved in the pathogenesis of Meniere's disease.
However, the etiology remains to be clarified. Magnetic resonance imaging (MRI) facilitates visualization of the inner ear structure, and is useful for physiological and pharmacological evaluation. In this study, we conducted high-magnetic-field MRI in mice to visualize endolymphatic hydrops. An endolymphatic hydrop model, PhexHyp-Duk/Y mice, was used, as well as a 7T MRI device. Using the 7.05T MRI device, inner ear imaging was performed. In the PhexHyp-Duk/Y mice, the presence of endolymphatic hydrops was confirmed.

Free Research Field

耳鼻咽喉科

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Published: 2016-06-03  

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