2014 Fiscal Year Final Research Report
Examination of inner ears of mice using 7T MRI and molecular biologic analysis
| Project/Area Number |
24791813
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
NAKAMURA Manabu 聖マリアンナ医科大学, 医学部, 助教 (60386969)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | MRI / 内リンパ水腫 |
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| Outline of Final Research Achievements |
Endolymphatic hydrops may be involved in the pathogenesis of Meniere's disease.
However, the etiology remains to be clarified. Magnetic resonance imaging (MRI) facilitates visualization of the inner ear structure, and is useful for physiological and pharmacological evaluation. In this study, we conducted high-magnetic-field MRI in mice to visualize endolymphatic hydrops. An endolymphatic hydrop model, PhexHyp-Duk/Y mice, was used, as well as a 7T MRI device. Using the 7.05T MRI device, inner ear imaging was performed. In the PhexHyp-Duk/Y mice, the presence of endolymphatic hydrops was confirmed.
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| Free Research Field |
耳鼻咽喉科
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