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2014 Fiscal Year Final Research Report

PKC-delta targeted treatment of proliferative vitreoretinopathy

Research Project

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Project/Area Number 24791862
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionOita University

Principal Investigator

YOKOYAMA Katsuhiko  大分大学, 医学部, 助教 (90464461)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords増殖硝子体網膜症 / PKC δ / TGF-β / RPE / Ⅰ型コラーゲン
Outline of Final Research Achievements

Proliferative vitreoretinopathy (PVR) is severe complication after surgery of rhegmatogenous retinal detachment. Proliferative membrane, which is formed in the vitreous cavity and on the inner or outer surfaces of the neural retina, causes of PVR. It is thought that retinal pigment epithelium (RPE) cells could contribute to formation of proliferative membrane through production of collagen. In this study, we focused on PKC-δ which specifically express in proliferative membrane and analyzed about role of PKC-δ on collagen production system in RPE cells. For in vitro experiment, human RPE cell line (ARPE-19) was used. As results, we clarified that PKC-δ increase the typeⅠ collagen production in ARPE-19 cells. We expect that our findings contribute to development of novel therapeutic medicine targeting PKC-δ for PVR.

Free Research Field

眼科学

URL: 

Published: 2016-06-03  

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