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2014 Fiscal Year Final Research Report

Analysis of hypersensitivity reactions to titanium

Research Project

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Project/Area Number 24792091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

WATANABE Megumi  徳島大学, 大学病院, 講師 (40380050)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords金属アレルギー / 樹状細胞 / 歯科金属 / チタン
Outline of Final Research Achievements

We applied the method of nickel allergy mouse model to induce allergic reactions to titanium. To induce a hypersensitivity reaction to titanium, titanium oxide with IFA was intraperitoneally injected into B6 mice for initial immunization. Two weeks later, mice were administered intradermal injections of titanium, titanium oxide with CFA for a recall immune response. Any inflammatory reactions were not detected in titanium-injected mice compared with controls.
Next we observed immune cell responses to titanium in vitro. Bone marrow derived dendritic cells were stimulated with titanium oxide and then inflammatory gene expressions and cytokine productions were analysed. However there there were no significant changes between titanium injected mice and controls.

Free Research Field

歯科補綴学

URL: 

Published: 2016-06-03  

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