A highly reliable alveolar bone regeneration using controlled release of FGF-2; tissue engineering with biologic proof

2015 Fiscal Year Final Research Report

• Project/Area Number: 24792190
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: KODAMA Naoki 新潟大学, 医歯学総合病院, 特任助教 (90572355)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: FGF2 / 骨再生 / 歯槽骨 / 遺伝子発現

Outline of Final Research Achievements

It is reported that FGF-2 which is an anti-ulcer drug causes a bone regeneration. We searched optimal condition of the murine alveolar bone regeneration in mouse by FGF -2. The controlled released 20 microgram FGF-2 using gelatin hydrogel occurred good bone regeneration. From histologic analysis, periosteum-related cortical bone addition was confirmed. Also, FGF-2 proliferated the osteoblasts which expressed the FGF receptor included in the periosteum and promoted a bone matrix production, and the additive bone regeneration to, as a result, existing bones was thought. Because a series of bone regeneration phenomena ended in four weeks, the possibility that the additive reproduction effect with repeated doses was obtained was suggested. Further analysis is expected.

Free Research Field

外科系歯学