2012 Fiscal Year Final Research Report
Antifibrotic effect and role of antibody to connective tissue growth factor in an animal model of scleroderma
| Project/Area Number |
24890076
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
CHUJO Sonoko 金沢大学, 大学病院, 助教 (20401911)
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| Project Period (FY) |
2012
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| Keywords | 強皮症 / 線維化 / CTGF |
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| Research Abstract |
We investigated antifibrotic effect of antibody to connective tissue growth factor (CTGF) in an animal model of skin fibrosis. Anti-CTGF antibody reduced skin fibrosis in a bleomycin-induced scleroderma mouse model and a tight skin mouse. It suggested that anti-CTGF antibody is capable of blocking the development of skin fibrosis in an animal model not induced by exogenous application of growth factors.
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