2013 Fiscal Year Final Research Report
Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment
| Project/Area Number |
24890113
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII Hiroshi 大阪大学, 大学院・医学系研究科, 助教 (90634171)
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| Project Period (FY) |
2012 – 2013
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| Keywords | 中枢神経損傷 / 獲得免疫系 / Th1細胞 / ミクログリア / マクロファージ |
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| Research Abstract |
We demonstrated that transfer ofproinflammatory Th1 cells unexpectedly promoted functional recovery after spinal cord injury(SCI). The effects of Th1 cells depended on expression of interferon-γ in Th1 cells as well as interleukin 10(IL-10)up-regulation from microglia and macrophages in the injured site. In addition, genetic deletion of IL-10 from Th1 cells abrogated complete effects of Th1 cell transfer.
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