2013 Fiscal Year Final Research Report
Construction of preventive approaches in pediatric dentistry field for inflammatory bowel diseases caused by oral bacteri
| Project/Area Number |
24890123
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
URATA Ayuchi 大阪大学, 歯学研究科(研究院), 特任研究員 (90589772)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 口腔細菌 / 炎症性腸疾患 / IFN-γ / サイトカイン / マウスモデル / 中和抗体 |
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| Research Abstract |
Streptococcus mutans, a major pathogen of dental caries, is known to invade the bloodstream and sometimes causes systemic diseases. The present study investigated the possible mechanism of aggravation of inflammatory bowel diseases caused by S. mutans. We found that hepatocytes invaded by S. mutans produced IFN-gamma, while alpha-AGP and amyloid A1 enhanced inflammation and unbalanced the immune system, leading to aggravation of inflammatory bowel diseases. In addition, it was shown that the neutralizing antibody against IFN-gamma improved the condition.
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[Journal Article] Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis2012
Author(s)
Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T
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Journal Title
Sci Rep
Volume: 2
Pages: 332
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