2013 Fiscal Year Final Research Report
Involvement of periodontal ligament cells in angiogenesis induced by FGF-2
| Project/Area Number |
24890125
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KOJIMA Yuko 大阪大学, 歯学研究科(研究院), 特任研究員 (90632141)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 血管新生 / FGF-2 / 歯根膜細胞 |
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| Research Abstract |
In this study, we examined whether FGF-2 could induce vascular endothelial growth factor (VEGF)-A expression in periodontal ligament (PDL) cells and whether cell-to-cell interaction between PDL cells and endothelial cells (EC) could stimulate angiogenesis. FGF-2 induced VEGF-A expression from PDL cells. FGF-2 and VEGF-A synergistically stimulated the migration of PDL cells. Time-lapse analysis revealed that PDL cells migrated close to the tube-forming EC, mimicking pericytes. These findings suggest that FGF-2 and FGF-2-induced VEGF-A, as well as cell-to-cell interactions between PDL cells and EC, create a suitable environment of periodontal regeneration by orchestrating angiogenesis at FGF-2-applied sites.
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