2013 Fiscal Year Final Research Report

BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)

Research Project

Project/Area Number	24890180
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Hematology
Research Institution	Sapporo Medical University
Principal Investigator	KAWANO Yutaka 札幌医科大学, 医学部, 助教 (80398320)
Project Period (FY)	2012 – 2013
Keywords	CD4調節性T細胞 / 慢性移植片対宿主病 / BH3プロファイリング
Research Abstract	BH3 profilings for CD4 positive regulatory (Treg) and non regulatory (Tcon) T cells were examined. Different priming between Treg and Tcon was associated to the effect of IL-2, especially on Treg, which contributes to cell survival. This profiling can explain how low dose IL-2 therapy works in patients with chronic graft-versus-host disease.

(1 results)