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2013 Fiscal Year Final Research Report

ER stress and presbycusis

Research Project

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Project/Area Number 24890231
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

OISHI Naoki  慶應義塾大学, 医学部, 講師 (10348740)

Project Period (FY) 2012-08-31 – 2014-03-31
Keywords内耳生化学 / 加齢性難聴 / 小胞体ストレス
Research Abstract

We tried to treat presbycusis by giving a ER stress-blocker, TUDCA, to different two types of mice. Presbycusis in one type of mice is promoted by progressive loss of auditory hair cells, which was not able to be attenuated by administratin of TUDCA. On the other hand, presbysis in the other type of mice which is promoted partly by loss of spiral ganglion cells was statistically significantly prevented by long-term continueous administration of TUDCA. The results were suggestive of future possibility of attenuating presbycusis by reducing ER stress.

  • Research Products

    (1 results)

All 2012

All Presentation (1 results)

  • [Presentation] Endoplasmic reticulum stress in aminoglycoside ototoxicity2012

    • Author(s)
      大石直樹
    • Organizer
      日本耳科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20121000

URL: 

Published: 2015-07-16  

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