• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Dynamics of Molecular Pattern Recognition in Protein Interaction

Research Project

  • PDF
Project/Area Number 25220205
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biomolecular chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

HAMAKUBO TAKAO  東京大学, 先端科学技術研究センター, 教授 (90198797)

Co-Investigator(Kenkyū-buntansha) 堀内 恵子  東京大学, 先端科学技術研究センター, 助教 (00456203)
太期 健二  東京大学, 先端科学技術研究センター, 特任助教 (20466866)
川村 猛  東京大学, アイソトープ総合センター, 准教授 (70306835)
篠田 恵子  東京大学, 先端科学技術研究センター, 特任助教 (80646951)
津本 浩平  東京大学, 大学院工学系研究科(工学部), 教授 (90271866)
岩成 宏子  東京大学, 先端科学技術研究センター, 准教授 (20176556)
Co-Investigator(Renkei-kenkyūsha) Fujitani Hideaki  東京大学, 先端科学技術研究センター, 特任教授 (50417151)
Nagatoishi Satoru  東京大学, 医科学研究所, 助教 (30550248)
Research Collaborator Yamashita Takefumi  東京大学, 先端科学技術研究センター, 特任准教授 (50615622)
Project Period (FY) 2013-05-31 – 2018-03-31
Keywords敗血症 / ヒストン障害 / ペントラキシン / RNAプロセッシング / 細胞周期
Outline of Final Research Achievements

In this study, we have analyzed the interaction pattern between PTX3 and histone, and obtained candidate molecules for regulating histone cytotoxicity in sepsis. Also we have detected direct interacting protein of WTAP and revealed the relation to alternative splicing of several target genes. We have obtained a candidate molecule which inhibits the interaction of WTAP and associating proteins. This should be a drug candidate as a RNA processing regulator in various biological phenomena. We identified a candidate peptide of aggregation prone part of PTX3 and interaction part in histone H3. Also we found the micro-particle release from histone damaged endothelial cells and developed specific antibodies to detect the identified marker proteins on the particle.

Free Research Field

生化学

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi