An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25253104
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontology
• Research Institution: Niigata University
• Principal Investigator: YOSHIE Hiromasa 新潟大学, 医歯学系, 教授 (20143787)
• Co-Investigator(Kenkyū-buntansha): 高柴 正悟 岡山大学, 医歯(薬)学総合研究科, 教授 (50226768) ; 永田 俊彦 徳島大学, 大学院医歯薬学研究部, 教授 (10127847) ; 三谷 章雄 愛知学院大学, 歯学部, 教授 (50329611) ; 石原 裕一 松本歯科大学, 歯学部, 教授 (50261011) ; 小林 哲夫 新潟大学, 医歯学総合病院, 准教授 (00215344) ; 木戸 淳一 徳島大学, 大学院医歯薬学研究部, 准教授 (10195315) ; 大森 一弘 岡山大学, 大学病院, 講師 (20549860) ; 前田 博史 大阪歯科大学, 歯学部, 教授 (00274001) ; 野口 俊英 愛知学院大学, 歯学部, 教授 (50014262)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: サイトカイン遺伝子 / 歯周炎 / 糖尿病 / 関節リウマチ

Outline of Final Research Achievements

The aim of this study was to identify the shared risk cytokine gene for periodontitis, diabetes mellitus (DM), and rheumatoid arthritis (RA). A total of 17 candidate single nucleotide polymorphisms were assessed in 185 patients with RA and chronic periodontitis (CP), 149 patients with type 2 DM and CP, 251 patients with CP, and 130 systemically and periodontally healthy controls from a cohort of Japanese adults. The results indicated that the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) rs2237892 and the peptidylarginine deiminase type 4 (PADI4)_104 rs1748033 polymorphisms were significantly associated with the comorbidity of RA and CP. Additionally, a trend toward increase was shown in the serum levels of anti-cyclic citrullinated peptide immunoglobulin G in the patients with RA and CP as compared to those with RA only. These results suggest that the KCNQ1 and possibly the PADI4_104 may constitute a shared risk gene for RA and CP in Japanese adults.

Free Research Field

歯周病学