2016 Fiscal Year Final Research Report
Integrated understanding of phosphate-sensing mechanism and its application for lifestyle disease prevention
| Project/Area Number |
25282022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Jin-ai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩野 正之 福井大学, 医学部, 教授 (20275324)
竹谷 豊 徳島大学, 大学院医歯薬学研究部, 教授 (30263825)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | リン / 感受性遺伝子 / 生活習慣病 / 日内リズム / 発達段階 |
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| Outline of Final Research Achievements |
In this study, we identified a novel phosphorus susceptibility gene by omics analysis and elucidated the molecular basis of the mechanism, and constructed a database of developmental stage / diurnal rhythm specific phosphorus sensing. As a result, as a phosphorus-sensitive gene, AMPK and Keap 1 which is regulator of intracellular signal molecules of Nrf 2 protein, clock protein, and these circadian related genes and detoxification related genes, and the regulation of expression mechanism of FGF23 and alpha-klotho essential for phosphorus; vitamin D metabolism and vitamin D metabolism-related enzymes. In addition, we developed and established a treatment method based on the phosphorus content in the meal to prevent the onset / development of lifestyle diseases targeting developmental stage and diurnal rhythm.
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| Free Research Field |
総合領域
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