2015 Fiscal Year Final Research Report
Re-evaluation of the basal ganglia network in rat
| Project/Area Number |
25282247
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KARUBE Fuyuki 同志社大学, 研究開発推進機構, 准教授 (60312279)
TAKAHASHI Susumu 同志社大学, 研究開発推進機構, 准教授 (20510960)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 視床 / 線条体 / 基底核 |
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| Outline of Final Research Achievements |
A fundamental organizing principle of the striatum is the striosome/matrix system that is defined by inputs/outputs and neurochemical markers. The thalamostriatal projection is highly heterogeneous originating in many subnuclei of the thalamus including the midline (ML) and intralaminar (IL) nuclei. In the striatum, ML neurons preferentially innervated striosomes, whereas parafascicular neurons preferentially innervated the matrix. Almost all single thalamostriatal neurons favoring striosome or matrix compartments also innervated the cerebral cortical area that supplied cortical input to the same striatal compartment. We thus revealed that thalamostriatal projections are highly organized 1) by the similarity in morphological characteristics and 2) their preference for the striatal compartments and cortical areas.
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| Free Research Field |
神経科学
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