Investigation of mass transfer in vascular endothelial cells by utilizing high-speed confocal PIV techqniue

2015 Fiscal Year Final Research Report

• Project/Area Number: 25289028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Tokyo Institute of Technology (2015); The University of Tokyo
• Principal Investigator: SUGII Yasuhiko 東京工業大学, 理工学研究科, 産学官連携研究員 (90345108)
• Co-Investigator(Kenkyū-buntansha): MOGI Katsuo 東京工業大学, 理工学研究科, 助教 (20610950) ; HISHIDA Koichi 慶應義塾大学, 理工学部, 教授 (40156592)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオ流体 / マイクロ流体 / 流体計測 / 共焦点マイクロPIV / 血管内皮細胞 / グリコカリックス

Outline of Final Research Achievements

In order to clarify Glycocalyx layer on vascular endothelial cells, a high resolution measurement technique for three-dimensional velocity distribution was developed by utilizing stealth fluorescent silica particles with a diameter of 100 nm coated with long chains of polyethylene glycol.. The developed technique was applied to endothelial cell cultured in a microfluidic device.

Free Research Field

流体工学