Regulation of higher brain function by lipid metabolism

2015 Fiscal Year Final Research Report

• Project/Area Number: 25290027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Wada Keiji 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長 (70250222)
• Co-Investigator(Renkei-kenkyūsha): SEKIGUCHI Masayuki 国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 (80260339) ; KABUTA Tomohiro 国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 (70535765)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脂質 / 高脂肪食 / マウス / オートファジー / 酸化ストレス / 生活習慣 / 母体 / ユビキチン

Outline of Final Research Achievements

We aimed to elucidate the relationship between lipid metabolism and brain function in the mouse. To achieve the goal, we focus on LAMP-2 protein, a member of the autophagy system, and UCH-L1, a deubiquitinating enzyme in the ubiquitin system. We also studied the effect of diet on the mouse brain function.
We observed that the LAMP-2 system was involved in various metabolism including nucleic acids, and that a mouse strain without UCH-L1 expression showed a delay of dendritic spine maturation in brain cortex. We also observed that maternal high fat intake at the lactation period resulted in the suppression of dendritic spine maturation.

Free Research Field

病態神経科学