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2015 Fiscal Year Final Research Report

Intracellular transprt of influenza virus genome

Research Project

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Project/Area Number 25293107
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Virology
Research InstitutionKyoto University (2015)
The University of Tokyo

Principal Investigator

Noda Takeshi  京都大学, ウイルス研究所, 教授 (00422410)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsインフルエンザ
Outline of Final Research Achievements

Influenza virus M2 protein plays an important role in the packaging of influenza virus ribonucleoprotein complexes (RNPs) into progeny virions. Our purpose of this study is to identify M2-interactiong host proteins that are involved in intracellular transport of M2 proteins and RNPs. First we identified that GBF1 interacted with M2 protein. Down regulation of GBF1 specifically inhibited the virus replication. Further experiments revealed that GBF1 is responsible for assembly and virus particle formation, but not for intracellular transport of RNPs.

Free Research Field

ウイルス学

URL: 

Published: 2017-05-10  

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