2015 Fiscal Year Annual Research Report
動脈壁と周囲脂肪組織における慢性炎症の可視化と病態解明
Project/Area Number |
25293184
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Research Institution | The University of Tokushima |
Principal Investigator |
佐田 政隆 徳島大学, 大学院医歯薬学研究部, 教授 (80345214)
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Co-Investigator(Kenkyū-buntansha) |
東邦 康智 東京大学, 医学部附属病院, 助教 (10586481)
福田 大受 徳島大学, 大学院医歯薬学研究部, 特任講師 (40637568)
堀川 一樹 徳島大学, 大学院医歯薬学研究部, 教授 (70420247)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 慢性炎症 / 動脈硬化 / 脂肪組織 / マクロファージ / 自然免疫 |
Outline of Annual Research Achievements |
慢性炎症の起点となるインフラマソームの活性化をCaspase1活性でFRETを用いて評価する系の確立を目指しているが、平成26年度実績報告書で報告したとおり研究遂行中に諸々の問題点が明らかとなり解決策を模索した。また、同時期に、同じ系を用いて、他のグループから、細胞レベルでCaspase-1 が活性化すると細胞にはすぐさま細胞死が生じるという論文が出版された(Liu et al. Cell Rep. 2014;8:974-982.)。当初、計画していた低強度の慢性炎症をin vivoで可視化することが困難なことが明らかとなった。そこで、方向転換して、肥満によって脂肪組織と血管壁で無菌的慢性炎症が惹起されるメカニズムの解明に取り組むことにした。 ヒトとマウスの両方で、肥満個体は、痩せた個体に比べて、脂肪細胞の変性に関連した血液中の遊離DNA断片の濃度が多く、血液中の遊離DNA断片の量がインスリン抵抗性の指標と相関した。また、変性脂肪細胞から遊離するDNA断片が、本来は細菌由来のDNA断片を認識するToll様受容体9(TLR9)によって認識され、マクロファージを活性化した。実際に、肥満マウスの脂肪組織内では、DNA断片を貪食しているマクロファージを免疫電子顕微鏡で捉えることができた。そして、TLR9欠損マウスでは、野生型マウスと同様の肥満を誘導しても、脂肪組織における炎症が軽度であり、インスリン感受性が保たれていた。骨髄移植により作出した骨髄由来細胞にのみTLR9を発現するマウスでは、脂肪組織の炎症とインスリン抵抗性が高度であった。また、マウスにTLR9の阻害オリゴヌクレオチドを投与することで、肥満に伴う脂肪組織の炎症とインスリン抵抗性の発症を抑えることができた。これらの結果から、肥満によって変性した脂肪細胞から遊離するDNA断片が、TLR9を介してマクロファージを活性化することで脂肪組織の慢性炎症とインスリン抵抗性を引き起こすことが明らかとなった。
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Research Progress Status |
27年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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Causes of Carryover |
27年度が最終年度であるため、記入しない。
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Expenditure Plan for Carryover Budget |
27年度が最終年度であるため、記入しない。
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Research Products
(212 results)
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[Journal Article] Effects of the addition of eicosapentaenoic acid to strong statin therapy on inflammatory cytokines and coronary plaque components assessed by integrated backscatter intravascular ultrasound.2016
Author(s)
Niki T, Wakatsuki T, Yamaguchi K, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Soeki T, Sata M
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Journal Title
Circ J.
Volume: 80
Pages: 450-460
DOI
Peer Reviewed / Open Access
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[Journal Article] Vegetation in the coronary sinus that concealed the presence of a coronary arteriovenous fistula in a patient with infectious endocarditis.2016
Author(s)
Takashima A, Yagi S, Yamaguchi K, Takagi E, Kanbara T, Ogawa H, Ise T, Kusunose K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Kitagawa T, Sata M
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Journal Title
Int J Cardiol.
Volume: 207
Pages: 266-268
DOI
Peer Reviewed
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[Journal Article] Report on the use of nonclinical studies in the regulatory evaluation of oncology drugs.2016
Author(s)
Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, SugiyamaY, Toi M, Irimura T
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Journal Title
Cancer Sci.
Volume: 107
Pages: 189-202
DOI
Peer Reviewed / Open Access
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[Journal Article] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.2016
Author(s)
Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
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Journal Title
Vascul Pharmacol.
Volume: 79
Pages: 16-23
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance.2016
Author(s)
Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama J, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M
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Journal Title
Sci Adv.
Volume: 2
Pages: e1501332
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial.2016
Author(s)
Tanaka A, Inoue T, Kitakaze M, Oyama J, Sata M, Taguchi I, Shimizu W, Watada H, Ako J, Sakata Y, Anzai T, Uematsu M, Suzuki M, Eguchi K, Yamashina A, Saito Y, Sato Y, Ueda S, Murohara T, Node K
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Journal Title
Cardiovasc Diabetol.
Volume: 15
Pages: 57-57
DOI
Peer Reviewed / Open Access
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[Journal Article] Noninvasive quantitative tissue characterization of carotid plaque using color-coded mapping based on ultrasound integrated backscatter.2016
Author(s)
Bando M, Yamada H, Kusunose K, Fukuda D, Amano R, Tamai R, Torii Y, Hirata Y, Nishio S, Satomi J, Nagahiro S, Sata M
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Journal Title
JACC Cardiovasc Imaging.
Volume: 9
Pages: 625-627
DOI
Peer Reviewed
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[Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.2016
Author(s)
Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H
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Journal Title
Oncogene.
Volume: 印刷中
Pages: 印刷中
DOI
Peer Reviewed
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[Journal Article] Response prediction and influence of tolvaptan in chronic heart failure patients considering the interaction of the renin-angiotensin-aldosterone system and arginine vasopressin.2016
Author(s)
Kadota M, Ise T, Yagi S, Iwase T, Akaike M, Ueno R, Kawabata Y, Hara T, Ogasawara K, Bando M, Bando S, Matsuura T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M
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Journal Title
Int Heart J.
Volume: 印刷中
Pages: 印刷中
Peer Reviewed / Open Access
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[Journal Article] Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.2016
Author(s)
Shimabukuro M , Sato H, Izaki H, Fukuda D, Uematsu E,Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama H, Masuzaki H, Sata M
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Journal Title
Biofactors.
Volume: 印刷中
Pages: 印刷中
DOI
Peer Reviewed
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[Journal Article] Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation.2016
Author(s)
Soeki T, Matsuura T, Bando S, Tobiume T, Uematsu E, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
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Journal Title
J Cardiol.
Volume: 印刷中
Pages: 印刷中
DOI
Peer Reviewed
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[Journal Article] Clinical utility of longitudinal strain distribution to predict functional recovery in patients with tachyarrhythmia and reduced ejection fraction.2016
Author(s)
Kusunose K, Torii Y, Yamada H, Nishio S, Hirata Y, Seno H, Saijo Y, Ise T, Yamaguchi K, Tobiume T, Yagi S, Soeki T, Wakatsuki T, Sata M
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Journal Title
JACC Cardiovasc Imaging.
Volume: 印刷中
Pages: 印刷中
Peer Reviewed
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[Journal Article] Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.2015
Author(s)
Yagi S, Takashima A, Mitsugi M, Wada T, Hotchi J, Aihara K, Hara T, Ishida M, Fukuda D, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
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Journal Title
Ther Clin Risk Manag.
Volume: 11
Pages: 83-88
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Impact of supervised cardiac rehabilitation on urinary albumin excretion in patients with cardiovascular disease.2015
Author(s)
Kimura S, Ueda Y, Ise T, Yagi S, Iwase T, Nishikawa K, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Katoh S, Akaike M, Yasui N, Sata M
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Journal Title
Int Heart J.
Volume: 56
Pages: 105-109
DOI
Peer Reviewed / Open Access
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[Journal Article] Plasma microRNA-100 is associated with coronary plaque vulnerability.2015
Author(s)
Soeki T, Yamaguchi K, Niki T, Uematsu E, Bando S, Matsuura T, Ise T, Kusunose K, Hotchi J, Tobiume T, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
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Journal Title
Circ J.
Volume: 79
Pages: 413-418
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.2015
Author(s)
Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
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Journal Title
J Atheroscler Thromb.
Volume: 22
Pages: 447-454
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Serial imaging changes during treatment of Immunogloblin G4-related disease with multiple pseudotumors.2015
Author(s)
Kusunose K, Hotchi J, Takagawa Y, Nishio S, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Soeki T, Wakatsuki T, Sata M
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Journal Title
Circulation.
Volume: 131
Pages: 1882-1883
DOI
Peer Reviewed
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[Journal Article] Prediction of future overt pulmonary hypertension by six-minute walk stress echocardiography in connective tissue disease.2015
Author(s)
Kusunose K, Yamada H, Hotchi J, Bando M, Nishio S, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Kishi J, Sata M
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Journal Title
J Am Coll Cardiol.
Volume: 66
Pages: 376-384
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound.2015
Author(s)
Yamazaki H, Yamaguchi K, Soeki T, Wakatsuki T, Niki T, Taketani Y, Kitaoka A, Kusunose K, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Sata M
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Journal Title
Circ J.
Volume: 79
Pages: 1773-1779
DOI
Peer Reviewed / Open Access
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[Journal Article] Comparison of carotid plaque tissue characteristics in patients with acute coronary syndrome or stable angina pectoris: assessment by iPlaque, transcutaneous carotid ultrasonography with integrated backscatter analysis.2015
Author(s)
Bando M, Yamada H, Kusunose K, Fukuda D, Amano R, Tamai R, Torii Y, Hirata Y, Nishio S, Yamaguchi K, Soeki T, Wakatsuki T, Sata M
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Journal Title
Cardiovasc Ultrasound.
Volume: 13
Pages: 34-34
DOI
Peer Reviewed / Open Access
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[Journal Article] Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.2015
Author(s)
Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
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Journal Title
Atherosclerosis.
Volume: 242
Pages: 407-414
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese.2015
Author(s)
Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A
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Journal Title
Atherosclerosis.
Volume: 242
Pages: 433-442
DOI
Peer Reviewed
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[Journal Article] Predictive factors for efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus.2015
Author(s)
Yagi S, Aihara K, Akaike M, Fukuda D, Salim HM, Ishida M, Matsuura T, Ise T, Yamaguchi K, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M. Matsumoto T, Sata M
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Journal Title
Diabetes Metab J.
Volume: 39
Pages: 342-347
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.2015
Author(s)
Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M
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Journal Title
Atherosclerosis.
Volume: 242
Pages: 639-646
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical utility of measuring epicardial adipose tissue thickness with echocardiography using a high-frequency linear probe in patients with coronary artery disease.2015
Author(s)
Hirata Y, Yamada H, Kusunose K, Iwase T, Nishio S, Hayashi S, BandoS, Amano R, Yamaguchi K, Soeki T, Wakatsuki T, Sata M
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Journal Title
J Am Soc Echocardiogr.
Volume: 28
Pages: 1240-1246
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Arterial stiffness is increased in young women with endometriosis.2015
Author(s)
Tani A, Yamamoto S, Maegawa M, Kunimi K, Matsui S, Keyama K, Kato T, Uemura H, Kuwahara A, Matsuzaki T, Yasui T, Kamada M, Soeki T, Sata M, Irahara M
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Journal Title
J Obstet Gynaecol.
Volume: 37
Pages: 711-715
DOI
Peer Reviewed
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[Journal Article] Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.2015
Author(s)
Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Nishimoto S, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
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Journal Title
Nutr J.
Volume: 14
Pages: 111-111
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of the endothelin receptor antagonist bosentan on hemodynamics and exercise capacity in Japanese patients with mildly symptomatic pulmonary arterial hypertension.2015
Author(s)
Hatano M, Yamada H, Fukuda K, Yoshioka K, Funauchi M, Kuwana M, Sata M, Taniguchi M, Nakanishi N, Saito T, Saji T, Sasayama S
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Journal Title
Heart Vessels.
Volume: 30
Pages: 798-804
DOI
Peer Reviewed
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[Journal Article] Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation.2015
Author(s)
Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Ishikawa Y
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 35
Pages: 2617-2625
DOI
Peer Reviewed
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[Journal Article] Effect of a low-intensity pulsed ultrasound device, SX-1001, on clinical symptoms in buerger disease with limb ischemia.2015
Author(s)
Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W
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Journal Title
Int Heart J.
Volume: 56
Pages: 632-638
DOI
Peer Reviewed / Open Access
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[Presentation] Reliability of Endothelial Function Assessment Using a Semi-automated Device across Multiple Institutions and Establishment of Normal/Reference Values.2016
Author(s)
Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Itoh H.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Epicardial Adipose Tissue Produce Proinflammatory Cytokines and Influence the Pathogenesis of Atrial Fibrillation2016
Author(s)
Matsuura T, Soeki T, Morimoto Y, Bando S, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice through GLP-1 Dependent Manner.2016
Author(s)
Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Plasma Myeloperoxidase Activity is Associated with Atrial Substrate Remodeling in Patients with Atrial Fibrillation.2016
Author(s)
Bando S, Soeki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Local Vascular Response after Paclitaxel Eluting Balloon Angioplasty Compared to Drug Eluting Stent Implantation in Stable Angina Patients.2016
Author(s)
Yamaguchi K, Wakatsuki T, Hara T, Kadota M, Ueno R, Bando M, Yamazaki H, Saito Y, Bando S, Matsuura T, Kusunose K, Ise T, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.2016
Author(s)
Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
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[Presentation] Echocardiographic Characteristics of Right Ventricular Size and Function are Associated with Cardiac Events in Sleep Apnea Syndrome.2016
Author(s)
Kusunose K, Yamada H, Nishio S, Hirata Y, Seno H, Saijo Y, Ise T, Tobiume T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Griffin B, Sata M
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター (宮城県仙台市)
Year and Date
2016-03-18 – 2016-03-20
Invited
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[Presentation] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice.2015
Author(s)
Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M
Organizer
CVMW 2015
Place of Presentation
神戸国際会議場(兵庫県神戸市)
Year and Date
2015-12-10 – 2015-12-12
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[Presentation] EATV is determinant for coronary atherosclerosis in men, but not in women: Analysis from patients underwent coronary artery bypass surgery.2015
Author(s)
Maimaituxun G, Shimabukuro M, Salim HM, Matsuura T, Yagi S, Fukuda D, Yamada H, Soeki T,Tabata M, Morimoto Y, Akasaka T, Tanaka M, Takanashi S, Sata M
Organizer
CVMW 2015
Place of Presentation
神戸国際会議場(兵庫県神戸市)
Year and Date
2015-12-10 – 2015-12-12
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[Presentation] Pressure-flow Relationship of Pulmonary Circulation Determines Six-minute Walk Distance in Connective Tissue Disease.2015
Author(s)
Kusunose K, Yamada H, Bando M, Nishio S, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Toll-like Receptor 9 Plays a Pivotal Role in Angiotensin II-induced Atherosclerosis.2015
Author(s)
Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.2015
Author(s)
Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice.2015
Author(s)
Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Combination Of Clinical, Electrocardiographic and Echocardiographic Parameters Predict the Onset of Atrial Fibrillation.2015
Author(s)
Soeki T, Bando S, Matsuura T, Tobiume T, Uematsu E, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Clinical Utility of Echocardiographic Epicardial Adipose Tissue Thickness Measured Using a High-frequency Linear Probe in Patients with Coronary Artery Disease.2015
Author(s)
Hirata Y, Yamada H, Kusunose K, Nishio S, Bando M, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Sata M
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Apolipoprotein-e Deficient Mice Through GLP-1 Dependent and Independent Manners.2015
Author(s)
Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M.
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] Atrial Late Potentials and Atrial Substrate Remodeling in Patients With Atrial Fibrillation.2015
Author(s)
Bando S, Soeki T, Matsuura T, Tobiume T, Ise T, Kusunose K, Yamaguchi K, Yagi S, Yamada H, Wakatsuki T, Sata M
Organizer
AHA Scientific Sessions 2015
Place of Presentation
Orange County Convention Center(Orlando, USA)
Year and Date
2015-11-07 – 2015-11-11
Int'l Joint Research
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[Presentation] The activation of toll-like receptor 9 deteriorates blood flow recovery after hind-limb ischemia.2015
Author(s)
Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M.
Organizer
ESC Congress 2015
Place of Presentation
ExCel London(London, UK)
Year and Date
2015-08-29 – 2015-09-02
Int'l Joint Research
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[Presentation] Impact of atrial fibrillation on tricuspid annular plane systolic excursion in patients without organic cardiovascular disease.2015
Author(s)
Torii Y, Kusunose K, Yamada H, Bando M, Hayashi S, Nishio S, Yamao M, Amano R, Hirata Y, Sata M.
Organizer
ASE 2015
Place of Presentation
John B. Hynes Veterans Memorial Convention Center(Boston, USA)
Year and Date
2015-06-12 – 2015-06-16
Int'l Joint Research
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[Presentation] Antiarrhythmic and Antiapoptotic Effects of C-type Natriuretic Peptide in Rats with Myocardial Ischemia/Reperfusion.2015
Author(s)
Soeki T, Matsuura T, Bando S, Tobiume T, Hara T, Takashima A, Bando M, Yamazaki H, Saito Y, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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[Presentation] Depot- and Gender-Specific Regulation of the Innate Immune System in Adipose Tissues: A Study from Human Biopsy Samples.2015
Author(s)
Shimabukuro M, Fukuda D, Sato H, Nishimoto S, Hara T, Takashima A, Hirata Y, Kurobe H, Yagi S, Soeki T, Izaki H, Sakaue H, Kitagawa T, Kanayama H, Sata M.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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[Presentation] Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.2015
Author(s)
Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata S.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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[Presentation] Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice.2015
Author(s)
Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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[Presentation] Differential Local Vascular Responses after Implantation of Biolimus-Eluting and Everolimus-Eluting Stents Compared with Sirolimus-Eluting and Bare Metal Stents.2015
Author(s)
Yamaguchi K, Wakatsuki T, Hara T, Takagawa Y, Bando M, Takashima A, Yamazaki H, Bando S, Matsuura T, Kusunose K, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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[Presentation] The Study to Evaluate the Effects of DPP-4 Inhibitor on Atherosclerosis in Patients with Diabetes Mellitus: PROLOGUE Study.2015
Author(s)
Node K, Oyama J, Ishizu T, Nanasato M, Kodama K, Bandoh Y, Kamiya H, Kitagawa K, Ueda S, Tomiyama H, Sata M, Maemura K, Matsuhisa M, Inoue T, Higashi Y, Yamada H, Ishihara M, Yamashina A, Kashihara N, Sato Y, Murohara T.
Organizer
第79回日本循環器学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2015-04-24 – 2015-04-26
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