Studies on a new treatment for influenza virus infection-induced asthma exacerbation by the inhibition of virus entry

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293189
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Yamaya Mutsuo 東北大学, 医学(系)研究科(研究院), 教授 (60261640)
• Co-Investigator(Kenkyū-buntansha): KAWASE Tetsuaki 東北大学, 医工学研究科, 教授 (50169728)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 呼吸器ウイルス感染症 / 気管支喘息 / 気道上皮細胞 / ウイルス感染制御 / 気道炎症

Outline of Final Research Achievements

Proteolytic activation of influenza virus hemagglutinin by the proteases, including type II transmembrane serine proteases which are expressed in the airway epithelial cells, enhances viral entry into cytoplasm, resulting in the next steps of viral replication. Viral replication, the release of inflammatory cytokine and cell damage are associated with symptoms, including fever and exacerbation of bronchial asthma. Because serine protease inhibitors reduce influenza viral replication by the inhibition of entry into cytoplasm, cytokine release and cell damage, the inhibitors are new potential candidate drugs for influenza virus infection-induced asthma exacerbation.

Free Research Field

呼吸器内科学：呼吸器ウイルス感染による気管支喘息および慢性閉塞性肺疾患の増悪の機序および治療法の研究