2016 Fiscal Year Final Research Report
Development of novel molecular diagnosis and therapy of malignant pleural mesothelioma
| Project/Area Number |
25293191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 悪性胸膜中皮腫 / バイオマーカー / 分子標的治療 |
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| Outline of Final Research Achievements |
We developed ELISA to analyze the concentration of novel target molecule for malignant pleural mesothelioma diagnosis and found that a comparison between mesothelioma patients including 18 cases of stage I and the healthy controls revealed an area under the curve of 0.9 (sensitivity and specificity > 90.0%). Thus level of target molecule in serum can discriminate surgically resectable malignant pleural mesothelioma patients from healthy individuals.
We also identified another molecule, which is aberrantly up-regulated in malignant pleural mesothelioma, and conducted functional analyses of it. We identified downstream pathway of it including kinase and phosphatase. Our findings shed light on the underlying mechanisms how the tumor cells manage cellular stresses commonly cased from surrounding microenvironment at both primary and metastatic sites.
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| Free Research Field |
分子腫瘍学
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