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2016 Fiscal Year Final Research Report

Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classification

Research Project

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Project/Area Number 25293284
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kure Medical Center (2016)
Hiroshima University (2013-2015)

Principal Investigator

Hinoi Takao  独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 臨床研究部室長 (10444689)

Co-Investigator(Renkei-kenkyūsha) SOTOMARU Yusuke  広島大学, 自然科学研究支援開発センター, 教授 (90309352)
IKENOUE Tsuneo  東京大学, 医科学研究所, 准教授 (80396712)
OUE Naohide  広島大学, 医歯薬保健学研究院, 准教授 (60346484)
TOMONAGA Takeshi  独立行政法人医薬基盤研究所, プロジェクトリーダー (80227644)
OHDAN Hideki  広島大学, 医歯薬保健学研究院, 教授 (10363061)
Research Collaborator ADACHI Tomohiro  
SAITO Yasufumi  
MIGUCHI Masashi  
NIITSU Hiroaki  
Project Period (FY) 2013-04-01 – 2017-03-31
Keywords大腸癌 / マウスモデル / バイオマーカー / RAS / TGFbetaRII
Outline of Final Research Achievements

We applied two types of genomic instability in advanced colon cancer mouse model (colonic epithelial cell specific conditional Apc-knockout mouse) that we established and added another carcinogen driver gene (Kras, TGFβIIR)mutation to Apc mutation to generate complex genetically modified mouse model. The tumor of Apc+Kras mutant mouse was moderately differentiated adenocarcinoma and by comprehensive gene analysis Glut1 and Rcan2 were identified as upregulated and downregluated target genes, respectively. In Apc + TGFβIIRk deficient mice, the expression of GSDMC transcript and protein was elevated. From these mice models, biomarkers useful for treatment such as correlation of genotype-phenotype of oncogenic driver gene and target gene could be identified.

Free Research Field

消化器外科

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Published: 2018-03-22  

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