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2015 Fiscal Year Final Research Report

Analysis of fibrodysplasia ossificans progressive by using iPSCs

Research Project

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Project/Area Number 25293320
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

Ikeya Makoto  京都大学, iPS細胞研究所, 准教授 (20442923)

Co-Investigator(Kenkyū-buntansha) TOGUCHIDA Junya  京都大学, 再生医科学研究所, 教授 (40273502)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Hidetoshi  京都大学, ips細胞研究所, 准教授 (80528745)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords異所性骨化
Outline of Final Research Achievements

Heterotypic ossification (HO) is an event that forms bone in mesenchymal tissues such as skeletal muscle, tendon, and ligament. Previously, it has been shown that growth factors such as bone morphogenetic protein (BMP), and artificial bone scaffold can induce HO, However, the molecular mechanisms and cell-of-origin of the HO is not fully elucidated. In this grant, we used patient-specific iPSCs generated from fibrodysplasia ossificans progressive (FOP-iPSCs) and mutation-corrected FOP-iPSCs (rescued FOP-iPSCs) as genetically-matched control cells, and analyze the molecular mechanisms underlying HO.

Free Research Field

発生生物学

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Published: 2017-05-10  

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