2015 Fiscal Year Final Research Report
Elucidating mechanisms of non-cell-autonomous osteoblast activation
| Project/Area Number |
25293327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
MATSUO Koichi 慶應義塾大学, 医学部, 教授 (40229422)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Ichiro 慶應義塾大学, 医学部, 特任講師 (50361655)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 骨芽細胞 / 骨形成 / 毛細血管 |
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| Outline of Final Research Achievements |
Transgenic mice overexpressing the transcription factor Fra-1 (Fra-1 mice) exhibit activation of bone-forming osteoblasts leading to enhanced bone formation. We therefore analyzed mechanisms by which bone formation is enhanced in Fra-1 mice. We found that "osteogenic capillaries" form bone matrix around the capillaries in the auditory ossicle malleus during endochondral ossification. We propose that Fra-1 overexpression enhances systemic bone formation by employing osteogenic capillaries in a cell-non-autonomous manner.
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| Free Research Field |
骨代謝学
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