Development of combination therapy, targeting NF-kB and CXCR4-related miRNA in oral cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: MIYAMOTO Youji 徳島大学, 大学院医歯薬学研究部, 教授 (20200214)
• Co-Investigator(Kenkyū-buntansha): UCHIDA Daisuke 獨協医科大学, 医学部, 准教授 (20335798) ; TAMATANI Tetsuya 徳島大学, 病院, 講師 (30274236) ; NAGAI Hirokazu 徳島大学, 大学院医歯薬学研究部, 准教授 (50282190) ; TAKAMARU Natsumi 徳島大学, 病院, 助教 (40513031) ; OHE Go 徳島大学, 病院, 助教 (60432762) ; KURIBAYASHI Nobuyuki 獨協医科大学, 医学部, 助教 (80617332)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CXCR4 / NF-kB / 口腔癌 / miRNA / 複合的治療法

Outline of Final Research Achievements

miR-146a negatively regulated the expression of CXCR4, a metastasis-related molecule, and the expression of EGFR and the activation of NF-kB, stimulators for cell growth. These results indicating that miR-146a may be a target of combination therapy for prevention of the growth and metastasis in oral cancer. However, this phenomenon occurred in vitro cell-type specific effect, in the future, it is necessary for the analysis of patient-derived xenograft model and/or for the investigation of the new miRNA cascade(s).

Free Research Field

口腔外科