In-situ Real-Time Monitoring of Volatile Organic Compound Exposure for Patients with Multiple Chemical Sensitivity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25340050
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Tokai University
• Principal Investigator: SAKABE Kou 東海大学, 医学部, 教授 (70162302)
• Co-Investigator(Renkei-kenkyūsha): TSUNODA Masashi 北里大学, 医学部医学科, 准教授 (00271221) ; TAKANO Hirohisa 京都大学, 大学院工学研究科, 教授 (60281698) ; KUNUGITA Naoki 国立保健医療科学院, 環境衛生部長 (90178020) ; TATEMICHI Masayuki 東海大学, 医学部医学科, 教授 (00318263) ; MATSUDA Tetsuya 玉川大学, 脳科学研究所, 教授 (30384720)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 化学物質過敏症 / 自律神経機能 / 揮発性有機化合物 / 条件づけ / 嗅覚過敏 / 心身相関 / 不安障害 / 不定愁訴

Outline of Final Research Achievements

In-situ real-time monitoring of volatile organic compound (VOC) exposure and autonomic nervous function（ANSF) were conducted for eight multiple chemical sensitivity (MCS) patients. １）VOC exposure, and ANSF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed. 2) We observed significant activations in the prefrontal cortex (PFC) during olfactory stimulation using several different odorants in patients with MCS by NIRS imaging. The study also included a subjective assessment of the physical and psychological status and of the perception of irritating and hedonic odors.

Free Research Field

環境生命医学