Exploration for and evaluation of anti-diabetic spice component through activating insulin signaling

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Osaka Prefecture University
• Principal Investigator: Akagawa Mitsugu 大阪府立大学, 生命環境科学研究科(系), 講師 (70405356)
• Co-Investigator(Renkei-kenkyūsha): ISHII Takeshi 神戸学院大学, 栄養学部, 准教授 (50448700) ; SHIBATA Takahiro 名古屋大学, 生命農学研究科, 准教授 (80447838) ; KAI Kenji 大阪府立大学, 大学院生命環境科学研究科, 講師 (40508404)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 香辛料 / 機能性食品 / ２型糖尿病 / インスリン抵抗性 / プロテインチロシンホスファターゼ1B

Outline of Final Research Achievements

In this study, we searched for insulin signal-activating component from spices and evaluated its anti-diabetic effects. We demonstrated that isothiocyanates found in cruciferous vegetables potently inhibits protein tyrosine phosphatase 1B (PTP1B), which negatively regulates insulin signaling. Moreover, we found that phenethyl isothiocyanate induces the ligand-independent activation of insulin signaling by inhibiting cellular PTP1B and increases glucose uptake in mouse C2C12 myotubes.

Free Research Field

食品機能化学