医学部及び医学研究科におけるグローバル化促進のための英語教育プログラム

2015 Fiscal Year Annual Research Report

• Project/Area Number: 25350221
• Research Institution: Hokkaido University
• Principal Investigator: Amengual Olga 北海道大学, 医学(系)研究科(研究院), 助教 (10636939)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: medical education / medical English / communication skills / research survey

Outline of Annual Research Achievements

We implemented 3rd year English Medical Program. During the academic year 2015, 105 regular English seminar(ES) were organized for graduate students (28 participants,21M).The median [range] of participation and of oral presentations at ES were 16[14-19] and 7[6-9],respectively. For 5th year medical students,20 problem based learning ES were organized (91 participants,65M,98% participation rate).
Thirty-three graduate students attended the ES at least during one academic year (April 2013 to March 2016). Thirty-one(97%) fully completed initial/final research surveys and subsequently analyzed. In the control group (graduates students from pneumology,orthopaedics,gastroenterology and digestive surgery departments whom did not join the ES),among 144 students invited to participate only 9(6%) completed both surveys. Self-confidence scores for communicative tasks in English and Japanese, were rated using visual analogue scales(VAS). Statistically significant improvements in VAS scores to perform long oral presentation in English and Japanese (p<0.0001 and p=0.01, respectively) and other communication tasks in English were observed following participation in ES. In the control group, no improvement was found in the self-confidence scores for any of the evaluated communication tasks after the observation period.
We validated, in a new cohort of 2nd year medical students attending to a 16-week medical English(MEC) our previous data showing that participation in MEC leads to improvements in self-confidence to discuss medical topics and to give medical oral presentations(p<0.0001).

Research Products

• [Int'l Joint Research] バルセロナ大学医学部自己免疫疾患科/InMusc, 骨格系医学教育学校(Spain)
  • Country Name: Spain
  • Counterpart Institution: バルセロナ大学医学部自己免疫疾患科/InMusc, 骨格系医学教育学校
• [Journal Article] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes. (2016)
  • Author(s): Fujieda Y, Amengual O, Matsumoto M, Kuroki K, Takahashi H, Kono M, Kurita T, Otomo K, Kato M, Oku K, Bohgaki T, Horita T, Yasuda S, Maenaka K, Hatakeyama S, Nakayama KI, Atsumi T.
  • Journal Title: Rheumatology (Oxford) Volume: in press Pages: in press
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Complement and thrombosis in the antiphospholipid syndrome. (2016)
  • Author(s): Oku K, Nakamura H, Kono M, Ohmura K, Kato M, Bohgaki T, Horita T, Yasuda S,Amengual O, Atsumi T
  • Journal Title: Autoimmune Reviews Volume: in press Pages: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autoantibodies against component 1q subcomponent (C1q), contribute to complement activation and recurrent thrombosis/pregnancy morbidity in antiphospholipid syndrome (APS) (2016)
  • Author(s): Oku K, Amengual O, Hisada R, Ohmura K, Nakagawa I, Watanabe T, Bohgaki T, Horita T,Yasuda S, Atsumi T
  • Journal Title: Rheumatology (Oxford) Volume: in press Pages: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein I antibodies. (2016)
  • Author(s): Otomo K, Amengual O, Fujieda Y, Nakagawa H, Kato M, Oku K, Horita T, Yasuda S, Matsumoto M, Nakayama KI, Hatakeyama S, Koike T, Atsumi T.
  • Journal Title: Lupus Volume: in press Pages: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Primary prophylaxis to prevent obstetric complications in asymptomatic women with antiphospholipid antibodies: a systematic review. (2015)
  • Author(s): Amengual O*, Fujita D, Ota E, Carmona K, Oku K, Sugiura-Ogasawara M, Murashima A, Atsumi T
  • Journal Title: Lupus Volume: 24 Pages: 1135-1142
  • DOI: 10.1177/0961203315578765
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An independent validation of the global anti-phospholipid syndrome scores in a Japanese cohort of patients with autoimmune diseases. (2015)
  • Author(s): Oku K, Amengual O, Bohgaki T, Horita T, Yasuda S and Atsumi T
  • Journal Title: Lupus Volume: 24 Pages: 774-775
  • DOI: 10.1177/0961203314561284.
  • Peer Reviewed / Open Access
• [Journal Article] The function and the significance of full-automated tests for detecting antiphospholipid antibodies. (2015)
  • Author(s): Oku K, Amengual O, Hisada R, Oomura K, Nakagawa N, Watanabe T, Bohgaki T, Horita T, Yasuda S, Atsumi T.
  • Journal Title: Japanese Journal of Clinical Immunology Volume: 38 Pages: 157-163
  • DOI: 10.2177/jsci.38.157
  • Peer Reviewed / Open Access
• [Journal Article] Educational improvement in Medical English Practice: Questionnaire survey to sophomore medical students of Hokkaido University. Hokkaido (2015)
  • Author(s): Murakami M, Amengual O, Iguchi K, Otaki J.
  • Journal Title: Hokkaido Journal of Medical Science. Volume: 90 Pages: 99-104
  • Peer Reviewed / Open Access
• [Presentation] Procoagulant property of a novel patient-derived autoimmune IgG type monoclonal anticardiolipin antibody that binds to beta 2 glycoprotein domain I but not to total beta 2 glycoprotein I molecule. (2015)
  • Author(s): Oku K, Kanetsuka Y, Amengual O, Nakamura H, Oomura K, Bohgaki T, Horita T,Yasuda S, de Laat B, Atsumi T.
  • Organizer: American College of Rheumatology, 79th Annual Scientific Meeting
  • Place of Presentation: San Francisco(USA)
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Reduction of HLA Class II expression and beta-2-Glycoprotein I presentation by fluvastatin in vitro and in vivo: possible mechanism of statin-induced-deprocoagulation in the antiphospholipid syndrome. (2015)
  • Author(s): Watanabe T, Oku K Amengual O, Hisada R Oomura K, Shida S, Shimizu Y, Kato M, Bohgaki T, Horita T, Yasuda S, Ishizu A, Arase H, Atsumi T.
  • Organizer: American College of Rheumatology, 79th Annual Scientific Meeting
  • Place of Presentation: San Francisco(USA)
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Impact of a medical English program in communication skills of graduate medical students. (2015)
  • Author(s): Amengual O, Murakami M, Jego EH, Bohgaki T, Oku K, Otaki J, Atsumi T.
  • Organizer: The annual meeting of the Spanish Society for medical Education.
  • Place of Presentation: Murcia(Spain)
  • Year and Date: 2015-09-28 – 2015-09-30
  • Int'l Joint Research / Invited
• [Presentation] Myxovirus resistance protein A (MX1) levels are elevated in T cells of the patients with SLE and serum Mx1 is a marker of neurophychiatric SLE. (2015)
  • Author(s): Yasuda S, Shimizu Y, Kono M, Shimamura S, Noguchi A, Shida H, Watanabe T, Kato M, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T
  • Organizer: 11th international Congress on Systemic Lupus Erythematosus
  • Place of Presentation: Vienna（Austria）
  • Year and Date: 2015-09-02 – 2015-09-06
  • Int'l Joint Research
• [Presentation] Impact of a medical English course on communication skills of medical students. (2015)
  • Author(s): Amengual O, Murakami M, Jego EH, Bohgaki T, Oku K, Otaki J and Atsumi T.
  • Organizer: The 47th Annual Meeting of the Japan Society for medical Education.
  • Place of Presentation: Toki Messe Niigata Convention Center（Ｎｉｉｇａｔａ）
  • Year and Date: 2015-07-24 – 2015-07-25
  • Int'l Joint Research
• [Presentation] Questionnaire survey to sophomore medical students of Hokkaido University.What they expect of Medical English Practice. (2015)
  • Author(s): Murakami M, Amengual O, Kawabata W，Kohonaba M, Otaki J.
  • Organizer: The 47th Annual Meeting of the Japan Society for medical Education.
  • Place of Presentation: Toki Messe Niigata Convention Center（Ｎｉｉｇａｔａ）
  • Year and Date: 2015-07-24 – 2015-07-25
  • Int'l Joint Research
• [Presentation] Predictive markers for thrombotic events in autoimmune diseases: comparison of Antiphospholipid Score (aPL-S) and Global Anti-phospholipid Syndrome Score (GAPSS). (2015)
  • Author(s): Oku K, Amengual O, Hisada R, Oomura K, Nakagawa I, Watanabe T, Bohgaki T, Horita T, Yasuda S, Atsumi T.
  • Organizer: International Society on Thrombosis and Haemostasis；ISTH2015
  • Place of Presentation: Ｔｏｒｏｎｔｏ（Cａｎａｄａ）
  • Year and Date: 2015-06-20 – 2015-06-25
  • Int'l Joint Research
• [Presentation] Overexpression of RasGRP4 in proliferative synovitis induces activation of Erk and p28-MAPK. (2015)
  • Author(s): Yasuda S, Shimamura S, Shimizu Y, KonoM, Shimizu T, Takahata M, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T.
  • Organizer: FOCis meeting2015
  • Place of Presentation: San Diego（USA）
  • Year and Date: 2015-06-20 – 2015-06-24
  • Int'l Joint Research
• [Presentation] Cardiac magnetic resonance imaging detects disease-specific biventricular involvement in patients with systemic sclerosis-associated pulmonary arterial hypertension. (2015)
  • Author(s): Noguchi A, Yasuda S, Kono M, Kato M, Oku K, Bohgaki T, Amengual O, Horita T, Sato T, Tsujino I, Nishimura M, Atsumi T.
  • Organizer: The Annual European Congress of Rheumatology EULAR
  • Place of Presentation: Rome（Italy）
  • Year and Date: 2015-06-10 – 2015-06-13
  • Int'l Joint Research
• [Presentation] Prophylaxis for the prevention of obstetric complications in asymptomatic women with antiphospholipid antibodies. (2015)
  • Author(s): Amengual O, Fujita D, Otta E, Carmona L, Kenji O, Sugiura-Ogasawara M, Murashima A, Atsumi T. Prophylaxis for the prevention of obstetric complications in asymptomatic women with antiphospholipid antibodies.
  • Organizer: The Annual European Congress of Rheumatology EULAR
  • Place of Presentation: Rome（Italy）
  • Year and Date: 2015-06-10 – 2015-06-13
  • Int'l Joint Research / Invited
• [Presentation] Significance of IgG phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results from the initial and validation studies. (2015)
  • Author(s): Amengual O, Forastiero R, Sugiura-Ogasawara M, Oku K, Otomo K, Alves JC. Favas C, Zigon P , Ambrozic A, Tomsic M, Ruiz-Irastorza G, Ruiz-Arruza I, Bertolaccini ML, Norman GL, Shums Z, Arai J, et al.
  • Organizer: The Annual European Congress of Rheumatology EULAR
  • Place of Presentation: Rome（Italy）
  • Year and Date: 2015-06-10 – 2015-06-13
  • Int'l Joint Research
• [Book] Laboratory Markers with clinical significance in the antiphospholipid Syndrome. In Antiphospholipid Syndrome in Systemic Autoimmune Diseases. (2016)
  • Author(s): Amengual O, Bertolaccini ML and Atsumi T.
  • Total Pages: in press
  • Publisher: Elsevier
• [Book] Systemic lupus erythematous basic, applied and clinical aspects (2016)
  • Author(s): Amengual O and Atsumi Tatsuya.
  • Total Pages: 571
  • Publisher: Academic Press