Study of optimal stimulation and mechanism of spinal cord stimulation for Parkinson disease with severe frozen gait.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kinki University
• Principal Investigator: NAKANO Naoki 近畿大学, 医学部, 講師 (60258027)
• Co-Investigator(Kenkyū-buntansha): KATO Amami 近畿大学, 医学部, 教授 (00233776)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: パーキンソン病 / 脊椎硬膜外刺激 / すくみ足

Outline of Final Research Achievements

A daily living of Parkinson’s disease was aggravated by a gait disturbance such as frozen gait. The The frozen gait could not be well improved by Levodopa and deep brain stimulation directly. A frozen gait was considered one of symptom of start hesitation. Some author reported that start hesitation was improved by visual cue, auditory cue and electrical stimulation. In recently, spinal cord stimulation(SCS) may alleviate motor dysfunction in Parkinson’s disease. The goal of this study is an investigation of mechanism of SCS in patients with Parkinson’s disease. We analyze a cerebral blood oxygenation in Parkinson’s disease with a spinal cord stimulation using near-infrared spectroscopy(NIRS) and/or scalp electroencephalogram. An improvement of gait disturbance result an increase of frontal brain area is measured during a stepping in NIRS. Based on their NIRS, we investigate that optimal parameter of SCS is decided such as low Hertz (<5Hz).

Free Research Field

脳神経外科