Dose glucocorticoid induce enhance hippocampal neurogenesis following a single bout of intense exercise?

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Nippon Medical School
• Principal Investigator: Mikami Toshio 日本医科大学, 医学部, 准教授 (60199966)
• Co-Investigator(Kenkyū-buntansha): OHTA Shigeo 日本医科大学, 大学院医学研究科, 教授 (00125832)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高強度運動 / 海馬 / 神経新生 / グルココルチコイド / 阻害剤 / ミフェプリストン / 脳由来神経栄養因子 / mRNA

Outline of Final Research Achievements

In this study, whether glucocorticoid has an effect on enhancement of hippocampal neurogenesis after a single of acute intense exercise is examined. The mice were intraperitoneally injected glucocorticoid receptor antagonist, mifepristone, 30 min befre exercise, subjected to a single bout of intense running on treadmill and excised immediately, 6, 12 and 24 h after exercise to examine neurogenesis and expression of brain-derived neurotrophic factor (BDNF). The findings suggested that the glucocorticoid increased after intense exercise has important effect on the enhancement of BDNF, which may be contributed to the increase of hippocampal neurogenesis caused by a single bout of intense exercise.

Free Research Field

運動生理学