Preparation of a biodegradable conjugate with carbon nanomaterial for targeted cancer therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25390024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials chemistry
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Zhang Minfang 国立研究開発法人産業技術総合研究所, ナノチューブ実用化研究センター, 主任研究員 (60518330)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: カーボンナノチューブ / カーボンナノホーン / 生分解 / 生体内分解 / ＤＤＳ

Outline of Final Research Achievements

Nanocarbons such as carbon nanotubes (CNTs) and nanohorns (CNHs) have recently garnered interest in the field of nanomedicine. However, the nanocarbons are easily accumulated by reticuloendothelial system such as liver or the spleen although it is less toxic. Understanding the long-term fate, health impact, excretion, and degradation of these materials have become crucial before practical uses. In this study, we have developed a new methodology for investigation of the biodegradation of CNHs in vitro and in vivo by using an optical absorption method. By using this methodology, the biodegradation degrees of CNHs with different sizes and surface modifications have been measured. The CNH-conjugate with easy degradation property has been prepared and its degradation possibility is investigated by in vivo test.

Free Research Field

ナノ・マイクロ科学