2015 Fiscal Year Final Research Report
Modulation and accumulation of bio-motors by micro electric fields
| Project/Area Number |
25390041
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Nano/Microsystems
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | アクトミオシン / モータータンパク質 / マイクロデリバリーシステム / 運動制御 / pH制御 / 温度依存性 |
|---|
| Outline of Final Research Achievements |
The motility of actin-myosin motor proteins is expected to be applied to micro-delivery system. The motility control in direction and in velocity is necessary for this purpose. In this study, we proposed temperature-control by application of current to electrically conductive glass and pH-control by application of voltage to micro Pt electrodes. Using these methods, the velocity of actin filaments driven by myosin motors with ATP hydrolysis could be reversibly increased and decreased in response to electrical input. However, the micro electric field could not induce an alignment of actin filaments during movement. In the context of micro delivery, actin-decorated micro-beads are capable of translocation between the actin and myosin.
|
| Free Research Field |
筋収縮の分子機構
|
