Convergent Synthesis of Biologically Active Natural Products via Segment Coupling Involving Ether Ring Formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25410118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Okayama University
• Principal Investigator: KADOTA Isao 岡山大学, 自然科学研究科, 教授 (30250666)
• Co-Investigator(Renkei-kenkyūsha): TAKAMURA Hiroyoshi 岡山大学, 大学院自然科学研究科, 助教 (70422798)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 全合成 / 海洋産天然物 / ポリ環状エーテル / 分子内アリル化 / 閉環メタセシス

Outline of Final Research Achievements

Secondary metabolites produced by marine organism have been recognized as novel read compounds for new drag due to their potent bioactivities. However, because of the limited availability from nature, chemical synthesis has been required to obtain sufficient amounts of these compounds. Moreover, the unusual structures are particularly attractive targets for synthetic chemists. In this study, synthesis of these marine natural products was investigated by using convergent synthetic methodology based on intramolecular allylation.

Free Research Field

有機合成化学