2015 Fiscal Year Final Research Report
Mechanisms of basal ganglia control of thalamocortical activity
Project/Area Number |
25430021
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | National Institute for Physiological Sciences |
Principal Investigator |
CHIKEN Satomi 生理学研究所, システム脳科学研究領域, 助教 (30396262)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 大脳基底核 / 視床 / 運動制御 / 神経活動 |
Outline of Final Research Achievements |
The basal ganglia receive inputs from the cerebral cortices and project back to the original cortices via the thalamus, and control voluntary movements. Thus, for elucidating roles of these structures on voluntary movements, it is crucial to understand how their outputs control thalamocortical activity. We recorded activity of identified thalamocortical neurons projecting to the motor cortices of macaque monkeys, and examined responses to electrical stimulation of the internal segment of the globus pallidus (GPi), output nucleus of the basal ganglia. During repetitive GPi stimulation at 50 or 100 Hz, each stimulus pulse evoked short-latency inhibition and following excitation. Local injection of gabazine, GABA-A receptor antagonist, in the vicinity of recorded neurons abolished both the inhibition and excitation without significant changes of spontaneous firing. The results suggest that basal ganglia outputs convey information through postinhibitory rebound excitation.
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Free Research Field |
神経生理学
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