Generation of the network modified mouse with disruption of amygdala-BNST connections

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Suto Fumikazu 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 室長 (40345848)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経科学 / 分子 / 発生・再生 / 神経回路形成 / 扁桃体 / 軸索誘導分子 / プレキシン / セマフォリン

Outline of Final Research Achievements

The amygdaloid network is a principal component of the limbic system with roles in emotion, feeding and sexual behavior. Axons of distinct amygdaloid　nuclei connect to the bed nucleus of the stria terminalis (BNST) in a topographic manner.　However, it remains largely unknown the roles　or contributions of this topographic connections for animal behavior. We have tried to generate the network modification animal restricted in amygdala-BNST connections. We generated the conditional targeting vectors for three axon guidance genes (plexin-A4, Sema6A. Sema6B), regulating the formation of the topographic connection, and established two ES cell lines with targeted recombination for plexin-A4.

Free Research Field

神経発生学