Analysis of inflammation and immune cells in tumor microenvironment.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Tohoku University
• Principal Investigator: Shirota Hidekazu 東北大学, 医学(系)研究科(研究院), 講師 (50451555)
• Co-Investigator(Kenkyū-buntansha): Ito Hiroyasu 岐阜大学, 医学系研究科, 准教授 (80373075)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍免疫 / 腫瘍微小環境 / T細胞 / マクロファージ / MDSC

Outline of Final Research Achievements

Tumor infiltrate leukocytes play an important role in tumor growth and metastasis. This study focused on these cells, examining tumor inflammation and classified the pattern of inflammation in colon cancer and clarified a role in tumor promotion. For example, (1) There are three classes of inflammation in colon cancer, due to a difference of tumor infiltrate leukocyte and cytokines. (2) We have reported that murine mMDSC express TLR9 and respond to stimulation by the TLR9 agonist CpG oligodeoxynucleotide (ODN) by differentiating into tumoricidal macrophages and human mMDSC respond to TLR7/8 agonists to differentiate into tumoricidal M1-like macrophages.

Free Research Field

腫瘍生物学