SOX17 suppression and inflammation in malignant cancer progression

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Oshima Hiroko 金沢大学, がん進展制御研究所, 准教授 (80362515)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: SOX17 / マウスモデル / 大腸がん

Outline of Final Research Achievements

Transcription factor SOX17 has been shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the roles of SOX17 in intestinal tumor development and malignant progression with submucosal invasion have been examined by mouse genetic studies. We found that SOX17 expression is induced by Wnt signaling-dependent manner in tumor cells. However, disruption of SOX17 gene did not cause any morphological change of intestinal tumors. Moreover, the number, size, and invasion status of intestinal tumors were not changed by SOX17 disruption. These results indicate that SOX17 is dispensable for intestinal tumor development and malignant progression.

Free Research Field

分子病理学