Analysis of p53/Mieap pathway in primary human cancer tissues

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Kamino Hiroki 国立研究開発法人国立がん研究センター, 研究所, 研究員 (00625692)
• Co-Investigator(Renkei-kenkyūsha): ARAKAWA HIROFUMI 国立研究開発法人国立がん研究センター, 研究所, 分野長 (70313088) ; NAKAMURA YASUYUKI 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 (90569063)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: p53

Outline of Final Research Achievements

The Mieap-regulated mitochondrial quality control is inactivated in 50～70% tumors of colorectal, pancreatic, breast, gastric, and esophageal cancer patients. As the result, unhealthy mitochondria dramatically and specifically accumulated in the cancer cells in the in vivo tumor microenvironment. The cancer-specific unhealthy mitochondria produce high level of reactive oxygen species, leading to the enhanced activities of cancer migration and invasion under hypoxic conditions. These results suggest that the Mieap-regulated mitochondrial quality control has a critical role in tumor suppression in the in vivo hypoxic tumor microenvironment.

Free Research Field

腫瘍生物学