2015 Fiscal Year Final Research Report
Augmentation of tumor immune response by depletion of regulatory T cells
| Project/Area Number |
25430161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
NAKAYAMA EIICHI 川崎医療福祉大学, 医療福祉学部, 教授 (60180428)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | がん免疫 / 腫瘍内浸潤リンパ球 / 制御性T細胞 / ケモカイン受容体CCR4 / ケモカインCCL22/MDC / 抗体依存性細胞障害性(ADCC) / ヒト化抗CCR4単クローン抗体 / 制御性T細胞除去 |
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| Outline of Final Research Achievements |
Augmentation of tumor immune response by depletion of regulatory T cells (Tregs) was pursued by the following studies. 1. On three Treg subpopulations, resting Tregs, activated Tregs and nonTregs, difference of the expression of CCR4 chemokine receptor on their surface and of their distribution in PBMC and TIL was demonstrated. 2. The presence of CCR4-expressing Tregs and CCL22/MDC in the local tumor site was shown by immunohistochemistry. 3. CD25 CD4 Tregs with migratory activity were shown to be eliminated by CCR4（KM2760）mAb with antibody-dependent cell-mediated cytotoxicity（ADCC）. 4. Efficient depletion of Tregs by injection of humanized anti-CCR4（ KW-0761）mAb in solid cancer patients was demonstrated.
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| Free Research Field |
腫瘍免疫
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