2016 Fiscal Year Final Research Report
Diversity of intercellular transfer of melanosomes
| Project/Area Number |
25440105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 細胞間輸送 / メラニン色素 / 色素細胞 / 表皮細胞 |
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| Outline of Final Research Achievements |
Skin pigmentation is achieved through an intercellular transfer of melanin pigments from melanocytes to surrounding keratinocytes. Our live imaging has visualized that the melanosomes are transferred via three pathways, membrane vesicles (small vesicles), filopodia and large vesicles. In this study, we attempted to understand molecular mechanisms and diversity of melanosome transfer. We first clarified that small GTPase Rho regulates membrane vesicles (small vesicles) by several different experiments. Second, we have identified keratinocyte-derived molecule that induce vesicle generation, especially larger vesicles. Finally, to understand conservation and diversity of intercellular transfer, we have examined extracellular vesicles from tumor cells during metastasis.
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| Free Research Field |
発生生物学
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