2015 Fiscal Year Final Research Report
Development of efficient method for synthesis of chemopreventors and study of its mechanism.
| Project/Area Number |
25460030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA MITSUYO 徳島文理大学, 大学院薬学研究科, 助教 (50148772)
KAKU HIROTO 徳島文理大学, 大学院薬学研究科, 準教授 (90299339)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 新光延試薬 / 不斉分子認識 / デラセミ化 / アブラムシ色素 / 不斉全合成 |
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| Outline of Final Research Achievements |
We developed efficient method to convert molecular structure utilizing new Mitsunobu reaction and kinetic molecular recognition. For example, the use of host molecule with alkaline converted racemic 3-benzy-2-hexanone and to the S-isomer of 99% ee in 93% yield. Furthermore, new Mitsunobu reagents such as CMBP and CMMP prepared were mediated C-C and C-N forming reaction in excellent yield. Utilizing these new reaction, we synthesized polyketide pigments of aphid.
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| Free Research Field |
有機合成化学
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