Studies on the mitochondrial proteins responsible for the traffic control across mitochondrial outer membrane, and its application for drug design

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: The University of Tokushima
• Principal Investigator: SHINOHARA Yasuo 徳島大学, 疾患プロテオゲノム研究センター, 教授 (60226157)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ミトコンドリア / 電位依存性アニオンチャネル / カルニチンパルミトイル転移酵素

Outline of Final Research Achievements

Mitochondrial outer membrane is highly permeable for various metabolites and ions. This high permeability is conferred by the voltage dependent anion channel expressed in the outer mitochondrial membrane. The carnitine palmitoyltransferase also present in the mitochondrial outer membrane is also responsible for the translocation of the fatty acids across mitochondrial membranes. In the present study, we focused on these two proteins, and tried to understand their structural and functional properties. These approaches are effective for better understanding of the properties of the mitochondrial outer membrane.

Free Research Field

生物系薬学