2015 Fiscal Year Final Research Report
Elucidation of neural control mechanisms by solute carrier OCTN1 and the application to treatment of depression
| Project/Area Number |
25460092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Yukio 金沢大学, 薬学系, 教授 (30251440)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体 |
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| Outline of Final Research Achievements |
To clarify the physiological role of solute carrier OCTN1 expressed in the central nervous system, we examined neural control mechanisms by OCTN1 and the possible application to treatment of depression. The obtained results suggest that OCTN1-mediated ergothioneine uptake may promote neuronal differentiation via activation of mTOR and induction of neurotrophic factors, orally ingested ergothioneine may promote neurogenesis in the hippocampal dentate gyrus and alleviate symptoms of depression via the effects, and OCTN1 may modulate the pharmacological effects of antidepressants.
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| Free Research Field |
細胞薬理学
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